In Donora, PA October of 1948 there was an inversion for four days, polluting the air with smog from nearby factories, resulting in 20 deaths and over 1\3 the population was sickened. Sixty years later, the New York Times considered it "One of the worst air pollution disaster in the nation's history".
Also another effect of temperature inversion can develop suppressed convection by acting as a "cap" which is a stable layer of the atmosphere that inhibits the development of convection. When the "cap" is broken for any reason a violent thunderstorms occurs and (or) freezing rain develops in typically colder climates.


Sources:
http://www.wikipedia.com/
http://www.awma.org/about/100years/pollresults2.html
http://hvo.wr.usgs.gov/volcanowatch/2005/05_07_28.html
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